Sentence examples for molecular subtypes the from inspiring English sources

The first part specifically focuses on ILC transcriptomic features by reviewing the intrinsic molecular subtypes, the application of gene expression scores for the prediction of recurrence, and the identification of gene expression subtypes.

In a cohort of breast cancer tissue samples a significant correlation among hMena, HER2 overexpression, the proliferation index (high Ki67), and phosphorylated MAPK and AKT was found and among the molecular subtypes the highest frequency of hMena overexpressing tumors was found in the HER2 subtype.

After adjusting for molecular subtypes, the levels of ER (P=0.009) and p53 (P=0.027) were independently associated with age but PR (0.872) and KI (P=0.246) were not.

With respect to intrinsic molecular subtypes, the therapy-predictive associations could not be resolved to the same degree as that of the prognostic associations observed in Nagalla et al. due to smaller sample sizes that prevented simultaneous stratification by both subtype and proliferation tertile.

Global expression profiling of large sets of tumors identified six molecular subtypes; the luminal A and luminal B subtypes (both estrogen receptor alpha-positive), the normal-like, HER2-positive, and basal subtypes (comprising triple-negative cancers) [ 2], and the claudin-low subtype [ 3].

For the analysis of molecular subtypes, the population differed from the overall study sample in that it comprised mostly racial/ethnic minority cases from Northern California and Ontario, as few non-Hispanic white families were enrolled in the BCFR after 2000 when HER2 data became available in the cancer registries.

When comparing survival according to molecular subtype, the luminal A subtype was associated with the best overall survival and the HER2-overexpressing subtype with the worst (Table 4).

With regard to molecular subtype, the tumor was hormone-positive, triple-negative and HER-2 positive in 87%, 8% and 5%, respectively.

Furthermore, this stratification should minimize the influence from the molecular subtypes, especially the effect of the HER2-enriched samples.

The expression of DYX1C1 among the molecular subtypes shows the lowest median expression within the basal type tumors, which are considered to have the worst prognosis.

The prevalence of the molecular subtypes in the gene expression cohort was similar to their prevalence in a large population of Californian women (Table 1).