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Prediction of intrinsic molecular subtypes revealed unequal distributions of subtypes within the metastatic and non-metastatic patient groups.
Data analysis across categories of molecular subtypes revealed significantly longer disease free and overall survival for screen detected cancers with a luminal A subtype only.
Data analysis across categories of molecular subtypes revealed significantly longer disease free and overall survival for screen detected cancers with a luminal A subtype only (p=0.01 and 0.02, respectively).
Two-tailed t-test correlation analysis grouping by molecular subtypes revealed moderate to highly significant positive correlations only between some tumour compartments (see italic lines in Table 3), while for the rest no relevant correlations were found.
Nevertheless, evaluation of the overall classification (82 pairs of samples) performance in the predicted intrinsic molecular subtypes revealed similar overall accuracies in all molecular subtypes (Additional file 1: Table S1).
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Detection of PCa molecular subtypes revealing the prognosis at an early stage of cancer development would be helpful in stratifying patients to personalized treatment.
Molecular subtyping revealed a strikingly low prevalence of ERG cancer with increased prevalence of SPINK1 cancer (dominant focus ERG 17%, SPINK1 26%, ERG/SPINK1 52%, single ERG/SPINK1 focus 4%).
Intrinsic molecular subtyping revealed that the hMSCs and hESC are identified as claudin-low and basal-like, respectively.
Rights & permissionsfor article Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions.
Based on the molecular differences between subtypes revealed in our study, biologists can look for better diagnostic biomarkers.
Signature gene profiles characterizing these two subtypes revealed that distinct molecular mechanisms might have been pre-programmed at an earlier stage in different subtypes of the disease.
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