Sentence examples for molecular subtypes identified from inspiring English sources
Similar to PFA ependymoma, there exists a significant intertumoral heterogeneity within PFB, with distinct molecular subtypes identified.
Moreover, we studied hMena distribution according to the molecular subtypes identified by a few protein biomarkers, namely ERα, PgR, HER2.
The molecular subtypes identified by Perou and colleagues [ 17] and Sørlie and colleagues [ 18] showed a striking difference in survival.
We show that expression data from FFPE material can be used to assign samples to intrinsic molecular subtypes identified using FF material.
The molecular subtypes identified are associated with significantly different clinical outcomes [ 4, 11] and are likely to respond best to different treatment approaches.
Nowadays, intrinsic molecular subtypes identified by global microarray-based gene expression analysis can be used to categorize breast cancer, which displays great diversity and molecular heterogeneity [ 11].
Unlike the analyses of individual biomarkers in the present cohort of patients [ 17] which showed high concordance between primary tumours and corresponding lymph node metastases, the molecular subtypes identify a subgroup of patients with ER positive disease as luminal B, with a worse prognosis, who may benefit from adjuvant chemotherapy alongside endocrine treatment [ 10, 14, 20].
Intrinsic molecular subtyping identified 19 (79 %) basal-like, 2 (8 %) HER2-enriched, and 3 (13 %) normal-like tumors.
Analysis of patient data for the 4 molecular subtypes we identified in the Thompson dataset confirmed our results for differences in metastasis, histology and age at diagnosis (Figure 7).
Five molecular subtypes were identified, characterized by WNT signaling (A; 9 cases), SHH signaling (B; 15 cases), expression of neuronal differentiation genes (C and D; 16 and 11 cases, respectively) or photoreceptor genes (D and E; both 11 cases).
All the intrinsic molecular subtypes were identified within TNBC, with BLBCs predominating (55 81.2%).
