Sentence examples for molecular subtypes generated from inspiring English sources

Our method of breast cancer molecular subtyping was also validated by the consistent correlations between the molecular subtypes generated by our classifier genes and the risk of distant recurrence predicted by the genes used in the Oncotype and MammaPrint predictors among three different datasets.

Furthermore, we have presented evidence that CRC cell line panels represent the different disease subtypes, and that the integration of pharmacology data offers new opportunities for develo-ping improved CRC therapies targeted at the new CRC molecular subtypes and generating clinically tractable hypotheses for response prediction.

The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of neuronal subtypes generated during development under precise molecular regulation.

Supplementary Figure S1 displays the bowel-subsite distribution of four molecular subtypes, which were generated by the combinatory status of CIMP and MSI.

The "intrinsic gene set" data generated by Sorlie et al. [2] to classify breast tumors into five molecular subtypes was used to filter cell line data generated by Charafe-Jauffret et al. [13].

Among the molecular subtypes of breast cancer identified through gene expression profiling studies, none has generated as much interest or controversy as the basal-like breast cancer group (BBC) [ 1].

In addition, we will be applying the model to a large cohort of breast tumors for which we have generated Affymetrix SNP 6.0 data with the goal of uncovering novel molecular subtypes.

In a previous study on the Tp53-null mouse mammary tumour model, researchers demonstrated that the generated tumours exhibit considerable heterogeneity and can be classified by transcript profiling into a variety of molecular subtypes, including one luminal, one claudin-low and two basal-like subtypes [ 22].

The present study also illustrates the ability of generating a biological hypothesis derived from the gene expression profiles of microarray-defined breast cancer molecular subtypes.

Next, we sought to identify associations with tumour molecular subtypes, and as an initial analysis chose the molecular subtypes of breast cancer, owing to both the well-defined subtypes and the relatively large number of cases available for each subtype.

Breast cancer is commonly classified into intrinsic molecular subtypes.