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Gene sets were selected from microarray data to assess proliferation and to classify breast cancers into four different molecular subtypes, designated Luminal, Normal-like, HER2+/ER-, and Basal-like.
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The single isolate with the molecular subtype designated A6 contains SCC mec IV, which is different from the other A-subtypes that contain SCC mec IIIb.
ENG and ALK-1 are found associated with two disease subtypes designated as HHT1 and HHT2, respectively.
Table 4 compared the results of PLS-regression and subtypes designated by SSP.
The muscarinic cholinergic family of G protein-coupled receptors (GPCRs) consists of five subtypes designated M1R-M5R.
Rare WHO subtypes designated as OTH were mucinous (2 PDAC and 1 DUOAC) and adenosquamous (3 PDAC).
A sample was designated as unclassifiable if none of the predicted probabilities of 5 molecular subtypes exceeded the threshold of 0.5.
To derive the "gold standard" for intrinsic subtype, centroid-based method (SSP) was used to designate each individual of the three studies into 1 of the 5 molecular subtypes.
Their overlap/similarities allow the definition of molecular subtypes.
Recently, comprehensive genomic studies defined three distinct molecular subtypes (TYR, MYC and SHH) of ATRT.
The mechanisms of speciation and inter-subtype transitions of these molecular subtypes require better characterization to facilitate the development of subtype-specific targeting strategies.
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