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Comparisons of the ages of patients and molecular subtypes between different geographic regions were performed.
Table 4 shows concordance rates for molecular subtypes between CNB and OEB.
Kappa test was applied to test concordance rates for ER, PR, HER2, and molecular subtypes between CNB and SRS.
Good agreement (κ = 0.658) was demonstrated in evaluating molecular subtypes between CNB and OEB, with a concordance rate of 77.2%.
No difference was found in the percentage of molecular subtypes between simple and complex/mixed carcinomas (Pearson =hi-square P = 0.47).
To our knowledge, this is the first study to evaluate the concordance of molecular subtypes between CNB and subsequent OEB samples in large series of breast cancer patients.
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In order to test for the homogeneity in the distribution of imunochistochemical markers for ER, PR, HER2, Ki-67, tumour grade and molecular subtype between the subgroups of BRCAX tumours, we used two-tailed Fisher's exact test.
No significant differences were found in the distribution of ER or PR markers, whereas there were significant differences in the expression of HER2 and molecular subtype between different BRCAX subgroups (Table 3).
Therefore, we compare miRNA-expression patterns between breast tumor samples classified according to the molecular subtypes and between breast tumor samples and normal breast samples.
Ovarian cancer is a complex disease with heterogeneity among the gene expression molecular subtypes (GEMS) between patients.
Differences in PTEN gene expression across the various intrinsic molecular subtypes and between brain metastases and other distant metastastic sites was evaluated by using a Wilcoxon rank sum test.
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