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High grade gliomas (HGGs) have been classified into three molecular subtypes based on similarity to defined expression signatures: Proneural (PN), Proliferative (Prolif) and Mesenchymal (MES) [32].
Worldwide, breast cancer is classified into molecular subtypes based on estrogen receptor (ER) and HER2 status.
Breast cancer samples were categorized into molecular subtypes based on immunohistochemical profiles.
Breast cancers of the luminal A and luminal B molecular subtypes (based on gene expression profiling) are typically ER+.
All cases were reclassified into molecular subtypes based on assessment of ER, PR, HER2, Ki67, CK5 and EGFR.
Breast cancer patients can be divided into five distinct molecular subtypes based on their expression profiles [ 4].
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A method of molecular subtyping based on 783 probe-sets was established and validated.
The prognostic value of molecular subtype based on immunohistochemistry is uncertain within the group of young breast cancer patients.
The BluePrint 80-gene classifier identifies "functional" molecular subtype based on intact molecular pathways associated with concordant mRNA and protein expression (1).
ER, PgR, Her2 and Ki-67 IHC were performed on the validation cohort, and used as surrogates for molecular subtyping, based on 13th St Gallen International Breast Cancer Conference (2013) Expert Panel recommendations [ 17].
We classified 5,687 invasive breast cancers by molecular subtype based on immunohistochemical expression of estrogen-receptor (ER), progesterone-receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 proliferation index.
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