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In the present study, only shifts to a molecular subtype with worse prognosis were observed.
Of the 295 data sets, 26 had unspecified molecular subtype with unknown ER, PR or HER2 expression status.
Group B was the most predominant molecular subtype with 68% (n = 126) of the strains in this cluster.
The TNBC phenotype is also acknowledged as an aggressive breast carcinoma molecular subtype with an early age of cancer onset and a high probability of metastases at presentation.
We used Cox proportional hazards univariate analysis to analyse the association between prognostic variables and molecular subtype with IBTR, LRR, metastases and breast cancer-specific death.
Considering that this conversion rate was similar within each molecular subtype, with an alpha error of 0.05 for a bilateral contrast and an accuracy of ±0.09 %, 43 patients would be needed for each molecular subtype, requiring 129 patients.
Similar(49)
Our understanding on the genetic alterations in gliomas has led to the recognition of several molecular subtypes with distinct clinical, prognostic, and imaging characteristics [9,10].
Recent findings indicate that PDAC, formerly presumed a homogeneous entity, has distinct morphological and molecular subtypes with different biological behavior and prognosis.
We hypothesized that variation in the transcriptional programming of AC tumors might distinguish molecular subtypes with differential outcomes after CRS/HIPEC.
Gene expression profiling of human breast cancers has identified a number of distinct molecular subtypes with different biological properties and prognoses [19].
The relatively poor outcome in adult ALL has been explained by an increased frequency of high-risk molecular subtypes with more aggressive clinical behavior and greater drug resistance, poorer tolerance and compliance with treatment, and less effective treatment regimens compared with childhood ALL [6], [8], [9].
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