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The frequency of RB1 LOH varied by molecular subtype (p = 0.0002) (Table 1).
Notably, the 'Crk gene signature' strongly correlated with the basal molecular subtype (P < 6.7e-14) in the NKI dataset [ 31].
For young patients, tumor size (P = 0.01), nodal status (P = 0.006) and molecular subtype (P = 0.02) were independent prognostic factors for overall survival.
Differences in the prevalence of subclonal CN loss events were observed between HER2-amplified/HER2-enriched and HER2-negative cases stratified by molecular subtype (P = 3 × 10-6, Chi-square test).
The protein level of RRBP1 is proved to be positively related to histological grade (P = 0.02), molecular subtype (P = 0.048) and status of Her-2 (P = 0.026) and P53 (P = 0.015).
Patients with tumors of Luminal A subtype had an increased mean age of 58.25 ± 1.827 years compared to 53.33 ± 1.153 years of those with tumors of Luminal B molecular subtype (p = 0.0182; Table 1).
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Moreover, premenopausal women diagnosed with triple negative cancer tumors had the lowest concentrations compared to those with the other three molecular subtypes (p = 0.002).
No differences were seen between the CMI of the different molecular subtypes (p = 0.199) (Online Resource Table 5).
When comparing BluePrint molecular subtyping with clinical stratification, the prognosis (10-year DMFS) was significantly different in 10-year DMFS between the different molecular subtypes (p < 0.001).
The basal-like group was also made up of a large number (31.6%) of medullary tumors, significantly more than in other molecular subtypes (p < 0.0001) (Table 3).
Concerning histological grade, Chi-square test showed that there was a significant association between grade and the different molecular subtypes (p < 0.0001).
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