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Radiogenomic analysis of breast cancer: luminal B molecular subtype is associated with enhancement dynamics at MR imaging.
Mazurowski et al [38] found that the Luminal B molecular subtype is associated with enhancement dynamics on MRI.
Hence, the determination of the molecular subtype is important for an individual prognosis and management.
Furthermore, this molecular subtype is refractory to anti-EGFR therapy (De Sousa et al, 2013).
In BWS, the determination of the molecular subtype is therefore important for an individual prognosis and therapy.
Molecular subtype is a strong independent prognostic factor in breast cancer patients younger than 40 years of age.
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The CLOVAR_MES_UP single-sample gene set enrichment analysis scores representing the mesenchymal molecular subtype were higher in paclitaxel responders than nonresponders (P = 0.002) in the GSE15622 data set.
Molecular subtype was determined on the basis of genomic analysis.
Associations between the imaging features and molecular subtype were evaluated by using logistic regression and likelihood ratio tests.
Mutation status for TP53 or PTEN, or with the aggressive integrative, transcript-based, or somatic copy number alteration-based molecular subtype were acquired from the Cancer Genome Atlas.
The CLOVAR_MES_UP single-sample gene set enrichment analysis scores representing the mesenchymal molecular subtype were higher in paclitaxel responders than nonresponders (P = 0.002) in the GSE15622 data set.
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