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The single isolate with the molecular subtype designated A6 contains SCC mec IV, which is different from the other A-subtypes that contain SCC mec IIIb.
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Gene sets were selected from microarray data to assess proliferation and to classify breast cancers into four different molecular subtypes, designated Luminal, Normal-like, HER2+/ER-, and Basal-like.
ENG and ALK-1 are found associated with two disease subtypes designated as HHT1 and HHT2, respectively.
Table 4 compared the results of PLS-regression and subtypes designated by SSP.
The muscarinic cholinergic family of G protein-coupled receptors (GPCRs) consists of five subtypes designated M1R-M5R.
The ability of a clinical scientist to readily designate the molecular subtype of a particular patient's tumor will allow the design of clinical trials that may enrich for patients more likely to benefit from a novel molecularly targeted therapeutic agent based on the signal transduction pathway activation status inherent in that tumor subgroup.
Bertucci, F., Finetti, P. & Birnbaum, D. Basal breast cancer: a complex and deadly molecular subtype.
Masuda, H. et al. Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers.
Finally, it increased the percentage of assigned luminal subtypes on the external ER-positive cohort and basal-like subtype on the external triple-negative cohort.Gene centering is often necessary to accurately apply a molecular subtype classifier.
Functional and developmental identification of a molecular subtype of brain serotonergic neuron specialized to regulate breathing dynamics.
Molecular subtype was determined on the basis of genomic analysis.
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