Sentence examples for molecular subtype defined from inspiring English sources

We found highly specific activation of a pathway involving MYCN, LIN28B, Let-7 and HMGA2 in the C5 molecular subtype defined by MYCN amplification and over-expression, over-expression of MYCN targets including the Let-7 repressor LIN28B, loss of Let-7 expression and HMGA2 amplification and over-expression.

Molecular subtype defined by IHC was an independent prognostic factor.

Histologic grade, ER status and molecular subtypes defined by ER, PR and HER2 were used as three independent prognostic characteristics for breast cancer.

This was already apparent in molecular subtypes defined by unsupervised expression profiling classification.

In a previous publication, we evaluated the prognostic impact of molecular subtypes defined by the immunohistochemical surrogate classification [ 24].

The classification of IBCA using IHC does not reflect all the molecular subtypes defined by gene expression.

We investigated the association between colocalization with the intrinsic molecular subtypes defined by the PAM50 gene set.

To our knowledge, this study is the first to examine the prognosis of DCIS in relation to different molecular subtypes defined by IHC.

Therefore, we performed a pairwise comparison of the different molecular subtypes, defined through mRNA-expression profiling, by using regression analysis with the limma-package.

The expression of miR-18a, along with other MIR17HG family members, was higher in basal-like tumors than in the other molecular subtypes defined by the PAM50 classifier [ 19].

Distinct mutation patterns were observed in the intrinsic molecular subtypes defined by the prediction analysis of microarrays-50 mRNA expression-based classifier (luminal A and B, HER2-enriched, and basal-like) [ 22].