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Molecular substitutions were specifically designed to investigate the role of hydrogen bonding at the active site of ALR2.
When this idea was first proposed, it was unknown whether molecular substitutions occurred with any clock-like regularity or if they tracked the irregular path of morphological evolution (Zuckerkandl 1987).
Planar aromatic hydrocarbons, such as benzene, C6H6, react with a wide variety of molecular substitutions.
For these reasons, our bottlenecking method was unlikely to cause large numbers of fixed molecular substitutions.
However, molecular substitutions per site could explain the role of distantly placed viruses and its possible neurovirulence in human host.
We note one important caveat in interpreting the phenotypic consequences of the molecular substitutions stems from our acquisition of clones from each population to conduct whole-genome sequencing.
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Vibrational spectroscopy (Raman and infrared) of ADTCH3 shows that the CO stretching modes from the oxocarbon and the aniline components are little affected by molecular substitution.
This finding demonstrates that changing the molecular substitution patterns could effectively alter and tune the light-emitting properties to greatly widen the scope of molecular candidates applicable in optical and optoelectronic fields.
Furthermore, the vibrational spectra of zalcitabine hydrochloride (5), isostructural to 1 but with a methylene moiety in the 3′-position of the five-membered ring instead of sulfur in lamivudine, have also been measured in order to point out the role of this molecular substitution and conformation in the vibrational modes of the salts.
In contrast, MG isolates share a molecular substitution characteristic of old genotypes as E104→G, in F protein [42], [58].
show a high molecular substitution rate in mitochondrial loci but little morphological diversification over millions of years [34].
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