Recently, CRCs were shown to belong to four different molecular subgroups, the so-called consensus molecular subtypes 1–432.
Taylor, M. D. et al. Molecular subgroups of medulloblastoma: the current consensus.
Ellison, D.W. et al. Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups.
Molecular subgroups were assigned based on the IHC surrogate proposed by the St. Gallen International Expert Consensus25.
Buczkowicz, P. et al. Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations.
(a) The HIT-SIOP-PNET4 clinical trial ran prior to the discovery of medulloblastoma molecular subgroups (2000 2007) and remnant tumour sample materials available were old, scant and unsuitable for array-based DNA methylomic subgrouping.
Derivation of the four consensus medulloblastoma molecular subgroups in a training cohort (n = 220) using genome-wide Illumina 450k DNA methylation microarray data.
(b) Non-negative matrix factorisation (NMF) consensus clustering identified four molecular subgroups (WNT, SHH, Grp3 and Grp4), defined by four metagenes.
Kool, M. et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.
Her lab has recently developed a personalized approach to identify molecular drivers of disease activity in pediatric lupus patients, allowing her team to classify patients into molecular subgroups.
