Sentence examples for molecular subgroups have from inspiring English sources

The molecular subgroups have been extended to also include a sixth subgroup which has been named the claudin- low group, based on its low expression level of tight junction genes (the claudin genes) [ 5].

Although the retrospective classification of various medulloblastoma cohorts into molecular subgroups has been scientifically insightful, medulloblastoma sub-grouping has not yet been applied in the setting of a prospective clinical trial for either patient stratification or patient selection for targeted therapy.

Molecular subgrouping has been documented as a useful clinical tool.

Importantly, all cases predicted to be WNT-driven medulloblastomas by molecular subgrouping had an exon 3 mutation in CTNNB1, and no CTNNB1 mutation was found in a non-WNT medulloblastoma (specificity = 1.000; 95 % CI 0.977 1.000 and sensitivity = 1.000; 95 % CI 0.782 1.000 when considering CTNNB1 mutation status as the "gold standard", Fig.  2b).

Additionally, as the subgroups have very different molecular genetic profiles, any successful strategies for targeted therapy will likely be subgroup specific (i.e., SMO inhibitors for SHH subgroup tumors).

While the molecular expression patterns of many genes and proteins in medulloblastoma subgroups have been discerned, subgroup-specific GPCR expression patterns have not previously been investigated.

Results based on smaller subgroups have a larger potential sampling error.

Three such subgroups have been suggested as one possibility.

Results among subgroups have a higher margin of error.

For each of these cohorts, molecular subgroup affiliation had been previously determined using either gene expression array profiling of matched frozen tissue, or IHC-based classification.

The recently-defined four molecular subgroups of medulloblastoma have required updating of our understanding of in vitro models to include molecular classification and risk stratification features from clinical practice.