Either experimental or clinical measures are required to better understand this latter relationship: the development of animal models, molecular studies defining more precise genotype/phenotype correlations as well as multicenter clinical studies with revision of clinical criteria for headache-/epilepsy-related disorders represent the start of future research.
Molecular studies defining the role of gene or protein expression signatures in development and adaptive strategies of marine larvae in the natural marine environment are limited.
However, molecular studies that define the diversity and abundance of microbes invading the amniotic cavity, and evaluate their clinical significance within a causal framework, are lacking.
Common experimental setups in molecular studies that define more than two groups are addressed by automated all-vs-all comparisons.
Together, the data present a portrait of the slow, step-wise emergence of virulence, setting the stage for further molecular studies that define the role of each gene acquisition event in the emergence of M. tuberculosis as an epidemic pathogen.
Prospective randomised trials are required, which should ideally incorporate comprehensive molecular studies to define subtypes most likely to respond; a related question is how to treat primary breast cancer in patients presenting with metastatic disease.
While these studies define certain molecular features of cetuximab response, their use as a modality for large-scale implementation has recognized limitations.
The present studies define a molecular mechanism for anti-angiogenic enhancement of tumor response to single dose radiotherapy via amplification of ceramide-driven endothelial apoptosis, converting transient tumor response to local cure.
These studies define specific molecular mechanisms and cellular pathways that, when perturbed by multiple gene variants, contribute to neuronal disease or dysfunction.
Latest studies define endotypes based on molecular and cellular mechanisms, for example defining risk and protective single nucleotide polymorphisms (SNPs) and new immune phenotypes, showing promising results.
