Sentence examples for molecular steps of from inspiring English sources

Collectively, the present study identifies molecular steps of insulin signaling in the liver and in the muscle that are similarly affected by two conditions that extend life, CR in normal animals and deletion of the GH receptor, but are not altered by CR in GHRKO mice in which CR fails to increase insulin sensitivity and therefore longevity.

111 Initially, rabbit reticulocyte lysate was most frequently used to investigate the molecular steps of protein translation in eukaryotic organisms.

The information available in the literature is not equally distributed over the molecular steps of the signal flow.

Moreover, it revealed a novel PTEN mutation with pathogenic effect, pointing out, however, the need for further efforts to elucidate the molecular steps of PTEN-associated carcinogenesis.

Even though critical molecular mechanisms of thyroid carcinogenesis have been clarified, other molecular steps of neoplastic progression need to be investigated.

We have hypothesised that HSP60 and HSP10 might be considered as new diagnostic and prognostic tools for these cancers [ 21, 22], being involved in the molecular steps of carcinogenesis, analogously to what has already been demonstrated with other tumours [ 23- 28].

Curved lateral faces of lamellar polymer crystals have previously been described mathematically using a model of initiation and spreading of molecular steps on the growth surface.

Deciphering the chronology and the significance of each molecular step of polarized growth is therefore very challenging.

To test this hypothesis and directly place α-SNAP in the molecular sequence of SOCE, we first asked whether the final molecular step of CAD domain mediated activation of SOCE via Orai1 is intact in α-SNAP depleted cells.

Although models always fail to capture the full complexity of immune responses, we posit that model building allows thorough, iterative interrogation of the sufficiency of molecular steps to account for large-scale functional properties (Kemp et al., 2007; Janes et al., 2008).

In the following sections, we provide a detailed summary of the cellular and molecular steps involved in each of these phases of lens development, from the initial induction of the lens ectoderm to the final stages of lens fiber maturation.