Sentence examples for molecular step in from inspiring English sources

Although each of these syndromes is clinically and pathologically distinct, it is interesting to note that they all share mTORC1 activation, which might be an early molecular step in tumor formation in each case.

These findings suggest that phosphorylation of Ser 473 in AKT is a key molecular step in the progression of RCC and could be a target for treating these tumors [ 25].

Because the key molecular step in the type I IFN production by pDCs in response to ligand for TLR7 or TLR9 has been elucidated to be nuclear translocation of the constitutive expression of IRF7 [ 3, 33], we assessed whether BAY11 inhibits this process in pDCs.

Taken together, it is possible that phosphorylation of Ser 473 on Akt is a key molecular step in the progression of RCC and a potential therapeutic target, so that the tumor level of phosphorylated Akt (Ser-473) may be useful for predicting the response to treatment.

The findings also identify the key molecular step in kinase activation: because C1A is already membrane-embedded in the kinase off state, recruitment of C1B to the bilayer by DAG or phorbol ester is the key regulatory event that stabilizes the kinase on state.

Thus, our results provide proof-of-concept for the use of reverse and forward yeast genetics to gain a genome-wide understanding of the molecular steps in PEA metabolism.

The early molecular steps in formation of melanoma are therefore the subjects of intense scrutiny.

One of the key molecular steps in the process of distant metastasis includes epithelial-to-mesenchymal transition (EMT) [ 22], which permits invasion and migration in CRC [ 23], and is associated with a poor prognosis in CRC [ 24].

In order to determine the molecular steps in A549 activation by endotoxin, studies with blocking antibodies targeting CD14 (MY-4, 5 μg/ml), TLR2 (TL2.1 10 μg/ml) or TLR4 (HTA105, 10 μg/ml) were performed.

The kinetics of WT Ure2 fibril formation has previously been analyzed in detail and monitoring of ThT fluorescence was shown to reliably reflect the extent of fibril formation, and can also shed light on the influence of internal and external factors on the rates of individual molecular steps in the fibril formation process.

With respect to ATP activation, previous work did not determine if molecular steps in the reaction coordinate for either hydroperoxidation or epoxidation are accelerated or if activation proceeds through an alternative process that does not affect the catalytic mechanism, such as protein stabilization.