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Molecular dynamics (MD) simulation was carried out to assess the molecular stability and flexibility profile of the structures.
These polymers of recombinant hemoglobin have the characteristics of molecular size, molecular stability, and oxygen delivery to hypoxic tissue suitable for an HBOC.
The absolute hardness and softness are important properties for measuring a molecular stability and reactivity.
Besides the above mentioned sources of heterogeneity, certain analytical procedures could introduce stress challenging molecular stability, and thus cause assay-induced heterogeneity.
Stxs, which are unique among bacterial toxins in sharing rRNA-N-glycosidase activity with plant RIPs [50], satisfy several principal challenges in oncology like molecular stability, and capabilities to cross physiologic barriers, and to withstand extracellular or intracellular degradation [32].
Whilst the maximum theoretical resolution of the proposed superlens may be very high (see e.g. Fig. 2 & Fig. 3), it will in practice be limited by the molecular brightness (photons emitted per molecule per second), the molecular stability, and noise.
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This possible approach would be of great interest in examining the truncation effects of the N- and C-termini of a protein on molecular stability, packing and ultimately crystallization.
Therefore, both evolutionary information and molecular stability must be considered in dealing with such an interdisciplinary subject.
In view of biochemical kinetics, it would be more helpful to incorporate, to further prior modelling, differences of time scales on each reaction speed, such as difference in molecular stability of different proteins and mRNAs.
Recent studies [9], including those from our group [10], demonstrate that confinement of biomolecules in nanostructured porous materials, with uniform pores slightly wider than the biomolecule, can significantly enhance molecular stability to proteases, temperature and solution conditions.
These studies focus on bridge-length optimization and amino acid chirality that may improve molecular stability against protease presents on plasma and result in longer time of action.
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