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TGF-β-SMAD signal transduction: molecular specificity and functional flexibility.
D'Elios, M. M. et al. Molecular specificity and functional properties of autoreactive T-cell response in human gastric autoimmunity.
TDP is coming of age for the identification, characterization, and direct quantification of proteoforms with total molecular specificity and recent applications of TDPs in translational research across cancer biology, heart disease and neurology will be surveyed.
These include intrinsically high sensitivity, molecular specificity, and tolerance to impurities as well as the simplicity and speed of the mass spectrometric measurements.
Recently, a new imaging modality named Optical Projection Tomography (OPT) [32] was developed to obtain molecular specificity and 3D cellular level resolution over complete specimens up to 1 cubic centimetre (cc) in size.
Therefore, the use of these substances in our studies was most of all motivated by their molecular specificity and not their (uncertain) clinical efficiency.
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Breast cancers, however, comprise histologically different tumor entities characterized by molecular specificities and differential prognosis [ 36, 37].
Tomographic approaches such as Diffuse Optical Tomography (DOT) [ 5– 8] and Fluorescence Molecular Tomography (FMT) increase the capabilities of optical imaging and offer many advantages including cost reduction, ease-of-use, molecular specificity, sensitivity and quantification accuracy [ 9– 11].
Recently, SAPNs have attracted special interest due to their unique properties, including molecular specificity, biodegradability, and biocompatibility.
Desirable characteristics of such a module are a high degree of molecular specificity, sensitivity, and dose-dependency.
In addition, aptamers possess numerous advantageous characteristics, including small size, lack of immunogenicity, easy and reproducible synthesis, high binding affinity and molecular specificity, fast tissue penetration and low toxicity, tenability in binding affinity, and long-term stability [ 14, 15].
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