Peptides are a promising drug scaffold because of their intermediate molecular size between that of therapeutic small molecules and antibodies.
Diffusion coupled with film disintegration is immediate (t B = 0) in case of encapsulated 5-FU as compared to the control film encapsulating microspheres characterized by t B = 70 min ± 7 min. This shift in release profile and the ability to modulate the timing of membrane burst can be attributed to the approximate ratio (1: 505) in molecular size between drug and microsphere.
The TERP passed through the NMWL 20,000 filter membrane, but did not pass through the NMWL 5,000 membrane, suggesting that the TERP is a protein with a molecular size between 5 and 20 kDa.
The difference of molecular size between rTbUNC119 and TbUNC119 was considered to be due to N-terminal additional peptides, including 6 X His-tag in rTbUNC119, which were encoded in the expression vector (11 aa; the calculated molecular mass was 1.5 kDa).
The difference in the molecular size between donor-isomers or between acceptor-isomers is small, <5%.
Finally, two loci were amplified by SSR primer pairs, which exhibited the same molecular size between TM-1 (Maxxa) and Hai7124 for each locus.
We surmise that past studies have been handicapped by solubility and membrane permeability issues, but primarily by the existence of an expansive taxane binding pocket and the discrepancy in molecular size between PTX and the pruned analogs.
The ZIP family of metal transporters shares several characteristics, including a molecular size between 36 and 39 kDa, 8 trans-membrane domains, a cytoplasmic 'variable region' localized between transmembrane domains 3 and 4 that provides a potential metal-binding domain and carboxy and amino termini located on the outer side of the targeted membrane [ 15, 21, 22].
Auto-processing of LmjMCA precursor polypeptide at arginine residues releases different forms of CD-LmjMCA with molecular sizes ranging between 10 and 35 kDa.
A comparison between pervaporation and gas separation results reveals that pervaporation membranes can tolerate a higher degree of interstitial defects than gas separation membranes because of stronger molecular interactions between the feed and the polymer, and the larger molecular size difference between penetrants in the former.
