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Having identified a putative post-cleavage cadherin-11 intracellular fragment with a molecular size consistent for CTF1, proteasome and γ-secretase activity was then targeted to confirm its identity by showing this fragment undergoes regulated intramembrane proteolysis to generate CTF2.
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For non-binding conditions, the trends in height equivalent to a theoretical plate (HETP) as a function of mobile phase velocity and molecular size are consistent with perfusion suggesting that a fraction of the mobile phase between 0.0005 and 0.0008 flows through the particles.
Analytical SEC clearly revealed that AZD9773 was capable of binding to multiple different sites on TNFα as the molecular size was consistent with approximately 12 Fabs bound per TNFα trimer.
Lactacystin-treated cells showed a dose-dependent accumulation of a low molecular fragment with a size consistent for CTF2 (Fig. 4c-d).
This finding is consistent with the molecular size of RLF/INSL3 in other species corresponding with pro-RLF/INSL3, as deduced from their cDNA sequences [ 11– 15].
The migration patterns of the HA0 precursor and HA1 of WSN/TatΔ51 59 virus were consistent with the molecular size expected for the chimeric HA/TatΔ51 59 protein).
A major protein band with a molecular weight of ∼62 kDa was detected (Figure 3C), which is consistent with the predicted molecular size of GRP78va.
The self-assembly of amphiphilic AB diblock copolymer in solution with different molecular size was investigated by using the self-consistent field theory (SCFT).
The micellar solubility and kS are significantly smaller for itraconazole than danazol, consistent with itraconazole's larger molecular size.
The presence of both kinds of small associated compounds in the same size fraction is consistent with its small nominal molecular size.
With additional methods applied, consistent compositional differences in attributes of surface charge distribution, molecular size, and spatial arrangement were observed.
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