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Peptides are a promising drug scaffold because of their intermediate molecular size between that of therapeutic small molecules and antibodies.
Diffusion coupled with film disintegration is immediate (t B = 0) in case of encapsulated 5-FU as compared to the control film encapsulating microspheres characterized by t B = 70 min ± 7 min. This shift in release profile and the ability to modulate the timing of membrane burst can be attributed to the approximate ratio (1: 505) in molecular size between drug and microsphere.
The TERP passed through the NMWL 20,000 filter membrane, but did not pass through the NMWL 5,000 membrane, suggesting that the TERP is a protein with a molecular size between 5 and 20 kDa.
The difference of molecular size between rTbUNC119 and TbUNC119 was considered to be due to N-terminal additional peptides, including 6 X His-tag in rTbUNC119, which were encoded in the expression vector (11 aa; the calculated molecular mass was 1.5 kDa).
The difference in the molecular size between donor-isomers or between acceptor-isomers is small, <5%.
Finally, two loci were amplified by SSR primer pairs, which exhibited the same molecular size between TM-1 (Maxxa) and Hai7124 for each locus.
Similar(52)
57 However, as these examples show, they have diverse depths and sizes of cavities and different ratios of molecular sizes between the enzyme and the inhibitor proteins.
A comparison between pervaporation and gas separation results reveals that pervaporation membranes can tolerate a higher degree of interstitial defects than gas separation membranes because of stronger molecular interactions between the feed and the polymer, and the larger molecular size difference between penetrants in the former.
The molecular size difference between the excised gel bands and the molecular size of the identified enzymes may be due to a degradation prior to the SDS-PAGE.
This number should not represent the ratio of the hydrodynamic radii of FU to DMFU because, as shown in Scheme 1, the molecular size difference between FU and DMFU cannot be so large even though they were not spherical and the effect of hydrations to the ratio were not considered.
This would explain the similarity in molecular size and function between wild type and mutant proteins.
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