Literature precedents indicate that lipophilic drugs readily cross the BBB, although other chemical characteristics, including the number of hydrogen bonds, molecular weight, polar surface area, and molecular size, are also known to be critical to passive transport.
The viscosity is dependent not only on molecular size, but also on the interactions between aromatic components or other compositional elements (linear vs. branched, etc).. Nonetheless to a first approximation, this may explain why the heaviest oil feed (Marmul) showed the best relative viscosity improvement.
The larger r1 relaxivities are in line with their larger molecular size and also more Gd-chelates in the probes.
It has been suggested that an increase in solubility of protein hydrolysates is due to the reduction of the molecular size and also due to the enzymatic release of smaller polypeptide units from the protein.
Molecular size of starch can also be controlled by the selective hydrolysis reaction such as 4-α-glucanotransferase that preferentially cleaves the α-1,4-glycosidic linkage of the glucan segment between the amylopectin clusters.
The likely reason for this phenomenon is that organic acids have slower ionization rates than HCl and also, the molecular size of citric acid is the largest among all the acids used in this study.
The latter, however, includes not only the anticipated binary effects (due to the co-existence of two components with different molecular size and adsorption capacity) but also additional nonlinear effects due to the direction of diffusive mass fluxes and to the lateral interactions of the adsorbed gas molecules in the micropores.
However, under non-reducing conditions, a second band with a molecular size of >100 kDa was also detected.
Although not a quantitative method like the above-mentioned ELISA assays, the present assay offers the advantage of not only demonstrating the presence or absence of ADAMTS13 antigen, but also the molecular size of ADAMTS13 present in plasma samples.
The method can also predict the molecular size.
