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The technique used to identify the Merkel cell polyoma virus eliminates known human molecular sequences from a sample of tissue, leaving unknown or nonhuman sequences that the scientists explore in seeking a possible infectious agent.
Assembly of molecular sequences from fragments predates the ability to sequence DNA.
Our analysis employed EST databases and new molecular sequences from closely related outgroup species generated with next-generation sequencing of cDNA.
Molecular sequences from a significant number of species have been published, but previous comparative or phylogenetic analyses have been limited to individual genomic sequences [e.g. [ 29]] or have not focused on Chl a/c sequences [e.g. [ 2]].
The use of similarity networks appears as a compelling complement to standard phylogenetic analyses in order to perform comparative analyses of an increasing amount of molecular sequences from genomic and metagenomic projects.
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The molecular sequence from adenoma to invasive cancer is well established, with the identification of misexpression and mutation of several genes (including rare inherited syndromes).
From the moment a patient arrives to a hospital or health centre until the processing and analysis of molecular sequences obtained from infectious pathogens in the laboratory, lots of information is collected from different sources.
Furthermore, molecular sequences suffer from the effects of a number of important constraints, including saturation by rapid mutational change (substitutions and indels), non-orthologous gene replacement, differential rates of evolution in lineages, horizontal gene transfer, lineage sorting by sequence polymorphisms, and paralogous relationships by gene or genome duplication [ 7- 9].
Here we brought into culture a novel photosynthetic Paulinella strain (FK01) and generated molecular sequence data from these cells and from four different cell samples, all isolated from freshwater habitats in Japan.
"The Kulindroplax fossil evidence," Briggs said, "confirms genetic evidence from molecular sequences in DNA and proteins that also refutes the traditional argument" and adds "that he would be surprised if the scientific community did not accept Kulindroplax as definitive evidence of the evolutionary history of mollusks".
Phylogenetic inference from molecular sequences is becoming an increasingly popular tool to trace the patterns of pathogen dispersal, especially for rapidly evolving RNA viruses [62], [63], [64], [65].
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