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Yamuna Krishnan, Ph.D., Professor of Chemistry at the University of Chicago, wrapped up the first session by recounting how her team used DNA nanotechnology to build "CalipHluor," a synthetic molecular sensor that detects both pH and calcium ion levels in intracellular organelles within cells in living worms with high accuracy.
He says the findings "yield definitive proof that TMC1 is the critical molecular sensor that converts sound and motion into electrical signals the brain can understand". "It is, indeed, the gatekeeper of hearing," he says.
Since G6PD is a major NADPH producing enzyme in cells, we hypothesized that there is a yet identified molecular sensor that respond to NADPH status in C. elegans.
The recent discovery of PHF8 as a molecular sensor that regulates ATRA response in APL has suggested a novel avenue for overcoming ATRA resistance.
Together, these studies reveal PHF8 as a key molecular sensor that governs ATRA response in APL.
Thus, it will be important to identify the specific molecular sensor that triggers p53-independent induction of the apoptotic machinery by rML.
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Researchers also mused about creating a "placenta on a chip" that would mimic the tissue in the lab or developing molecular sensors that could monitor the placenta throughout pregnancy.
KATP channel is a kind of molecular sensors that play a critical role in the adaptive response to both physiological and pathological stress [ 21, 22].
K-ATP channel is a kind of molecular sensors that plays a critical role in cardiovascular adaptive response under the challenge of stress [ 19].
This observation points to a previously unreported mechanism of regulation by a potential standalone small-molecular sensor that probably occurs at the level of protein-protein interactions rather than via the sensor domain of a one-component system transcription factor.
Catenins have emerged as molecular sensors that integrate cell-cell junctions and cytoskeletal dynamics with signaling pathways that govern morphogenesis, tissue homeostasis, and even intercellular communication between different cell types within a tissue.
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