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The molecular scaffolds generated as a result of clustering were thus used as SMILES query to search for substructures in both active and inactive target datasets.
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Here, the authors show that three-dimensional scaffolds generated from decellularized mouse thymus can support thymic epithelial cell survival in culture and maintain their unique molecular properties.
The scaffolds assembled using the Phusion-meta assembly method were much longer in length than the scaffolds generated using the SOAPdenovo program10 (Fig. 1a and Supplementary Table 1c).
First, the scaffolds generated by Scaffold Hunter mostly correspond to the scaffold assignments from Weber et al. which is demonstrated by the scaffold tree view.
Optical maps provide a coarse, genome-wide scaffold, in contrast, with the typically fragmented scaffolds generated from paired-end data.
After clustering using TGICL software [ 20], the 67,061 scaffolds generated 43,891 unigenes (a scaffold that matches no other scaffold) with a mean size of 668 bp.
Designed peptides may generate molecular scaffolds in the form of hydrogels to support tissue regeneration.
Specifically, the scaffold network generator (sng) tool [22], taking the input of SDF format of molecules, was used to generate the molecular scaffolds.
PDMs could be effectively used to systematically extract unique molecular scaffolds, which could further be chemically elaborated to generate novel leads and to screen molecules from drug-like libraries [ 5, 6].
Rudd, C.E. Adaptors and molecular scaffolds in immune cell signaling.
Lee, M. S. Turtle origins: insights from phylogenetic retrofitting and molecular scaffolds.
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