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Comprehensive binding studies with odorants could further corroborate the extent and overlap of molecular response profiles of OBPs.
This design enables us to assess whether or to what extent mating induces changes in molecular response profiles that would otherwise occur later in life.
Although molecular response profiles of odorant receptors have been well documented, the contributions of OBPs to olfactory behavior remain largely unknown.
In this article, we propose an enhanced Petri-Net (EPN) model to recognize the synergistic effects of drug combinations from the molecular response profiles, i.e. drug-treated microarray data.
Here, combinatorial activation of odorant receptors mediates olfactory discrimination in the main olfactory system (Malnic et al. 1999), whereas V1R pheromone receptors in the vomeronasal organ have highly specific molecular response profiles (Leinders-Zufall et al. 2000).
A comprehensive study of taste responses in subclasses of small, intermediate and large sensilla of the labellum characterized the molecular response profiles of 33 bitter taste receptors in all 31 labellar taste sensilla against a panel of 16 bitter compounds and identified four classes of bitter taste neurons (Weiss et al. 2011).
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Recognition of distinct lesions is important to factor into the study of breast cancer biology, in particular the design of study cohorts and trial analysis since they may present distinct molecular targets and/or response profiles.
L. rubellus has a complex response to contaminant exposure, but this can be efficiently analysed using molecular methods, revealing unique response profiles for different classes of effector.
PDXs exhibit morphology, molecular characteristics, and drug response profiles similar to those of the original patient tumors [ 9] and thereby represent a reliable model and a reproducible source for human tumor cells needed for detailed analyses of tumor cell subpopulations over time [ 9, 10].
We recently defined that the loss of effective immunity relates to the retardation in proper functioning of a highly complex network of hundreds of thousands of molecular signals between the biphasic response profiles of 2 biologically opposing arms, Yin (tumoricidal) and Yang (tumorigenic) properties of self terminating mechanisms of acute inflammation [6, 7].
To define the molecular response to baricitinib, we performed gene expression profiling of treated skin in both the prevention and treatment models.
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