"The bottom line of this idea," said Dr. Vahid Sandoghdar, a physicist at the University of Konstanz and the paper's senior author, "is if you can bring our molecule to an arbitrarily close distance, then we should get molecular resolution".
At a molecular level of resolution, we found that cellular responses to TGF-β are even more sensitive to contextual cues than was previously appreciated, which suggests that distinct TGF-β signatures may have to be generated for different tumor types or subtypes.
To discriminate these two hypotheses, we studied the nucleation of new spirals from pre-existing Snf7 assemblies at molecular resolution by HS-AFM.
These innovations will include the ability to detect disease from the presence of a few molecules; medical imaging at a level approaching molecular resolution; and targeted therapeutics capable of finding diseased tissue and delivering treatment to it and it alone.One example of the latter, developed by BIND Biosciences, which we co-founded, is known as BIND-014.
Cryo-electron tomography provides 3D views of cellular architecture with molecular resolution.
Scanning tunneling microscopy (STM) visualized porphyrin rings structure with molecular resolution.
Electron tomography can provide three-dimensional reconstructions of large pleomorphic structures at molecular resolution.
The samples appear flat and robust under SFM imaging conditions, both at low and molecular resolution.
Two ordered organic adlayers were found and imaged in situ with molecular resolution.
Advances in nanoscale imaging techniques especially synchrotron-based radiation enable the molecular cytogenetics for accurate visualization and analysis of chromosomes at molecular resolution.
