Sentence examples for molecular replacement solution from inspiring English sources

The utility of this approach is highlighted by the automated determination of a lysozyme mutant from a molecular replacement solution that is in congruence with a model prepared independently by crystallographers.

The molecular replacement solution was then subjected to automated model building in Phenix [29].

The initial molecular replacement solution was submitted to simulated annealing refinement.

The high quality electron density permitted direct modeling of the initial molecular replacement solution.

The quality of this molecular replacement solution was improved slightly by brief crystallographic refinement to 2.8 Å resolution in Refmac5.

Together with the unbiased features in the initial electron density, these data suggested a correct molecular replacement solution.

These molecular replacement solutions were used to determine and verify the positions of the selenium sites in the NG domain based on sequence alignments.

The phasing process was improved through the combination of anomalous Patterson and Fourier differences, based on partial molecular replacement solutions obtained using various NG domain structures (from Mja, Ssol and Taq) as search models to locate seleniums and improve phases.

Initial space groups were determined by using Pointless (Evans, 2006) and confirmed by decreases in both Rwork and Rfree after refinement of molecular replacement solutions.

Since each asymmetric unit in the two forms Natives 1 and 2 contained two monomers, it yielded 4-fold averaging, greatly improving the very poor phases coming from the weak molecular replacement solutions.

This example thus shows that weak high-resolution data (out to CC1/2 ∼ 0.2 and ⟨ I/σ⟩ ∼ 0.9 in this case) can help with challenging molecular replacement solutions as well as produce better refined models.