Sentence examples for molecular replacement problem from inspiring English sources

The structure of recombinant ValA from S. hygroscopicus 5008 presented a challenging molecular replacement problem, as the most similar known structures were only ∼30% identical in sequence.

However, their small size (18 kDa), very hydrophilic surface and repetitive structure can limit the DARPins' ability to provide essential crystal contacts and their usefulness as a search model for addressing the crystallographic phase problem in molecular replacement.

Das and Baker found that for 15 of 30 benchmark cases, R osetta de novo models successfully solved the phase problem by molecular replacement (43).

The final models were then used in molecular replacement to solve the crystallographic phase problem.

The phase problem was solved by molecular replacement using the crystal structure of Drosophila melanogaster sex-lethal protein (PDB code 3SXL) [18] as the search model in Phaser [19].

The phase problem was solved by molecular replacement with the program PHASER (McCoy et al, 2005) using as search model one monomer of the structure of the OBP from A. gambiae, AgamOBP1 (PDB 2ERB; [20]), edited with the chainsaw program [36].

The phase problem was solved using molecular replacement as implemented in MOLREP.

The phase problem was solved by molecular replacement using the ph stomatin domain as a search model, and the model was refined to an Rwork/ Rfree of 21.7/26.8% (Table I).

The phase problem was solved by molecular replacement using structures of the rod domain (PDB ID code 1HCI), the ABD from α-actinin-3 (PDB ID code 1WKU), and the NMR structure of EF3-4 (PDB ID code 1H8B) as search models.

The phase problem was initially solved by molecular replacement using MR-Rosetta with default settings.

The phase problem was solved by the automated molecular replacement pipeline BALBES; REFMAC was used for further refinement and iterated with model building using COOT.