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Collectively, these results support our hypothesis that Ang1 is a key molecular regulator of pathological vascularization characteristic of malignant astrocytomas.
Here we discuss an important molecular regulator of cell death, DAP-kinase (DAPk), which presents a promising target for therapeutic intervention.
Thus, ZEB1 is a central molecular regulator of a miRNA-mediated feedforward loop, which can re-enforce EMT.
Our results provide evidence for a previously unrecognised molecular regulator of pancreatic glucose-sensing and/or insulin secretion.
Taking essential roles in vascular development and remolding, Notch signaling pathway was upregulated in human AVMs and might be an important molecular regulator of AVM pathogenesis [ 71].
Hence, our data indicates a protective role for HoCC in PDAC and identifies Nupr1 as a molecular regulator of this process.
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Other up-regulated genes encode molecular regulators of energy metabolism.
PHDs (mainly PHD-2) were shown to represent the molecular regulators of HIF-1 activity regulating ubiquitination and subsequent proteasomal degradation of the HIF-1α subunit [26] [28].
Given these observations, it is not unreasonable to expect that the molecular regulators of these developmental changes might also regulate brca1 expression.
A number of key genetic and molecular regulators of yield component traits, especially seed size and number, have been identified.
Significant effort was dedicated to identifying the molecular regulators of these processes and the developmental defects resulting from gene modifications.
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