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Molecular recognition involves shape complementarity, with the ZMP 5-amino and carboxamide groups paired with the Watson-Crick edge of an invariant uracil, and the imidazole ring sandwiched between guanines, while the sugar hydroxyls form intermolecular hydrogen bond contacts.
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Second, we review molecular recognition involved in the formation of self-assembled monolayers.
ABS-Scan webserver can provide valuable insights on molecular recognition involving protein-ligand interactions.
Overcoming resistance problems requires first and foremost an integrated and systematic understanding of the structural determinants and molecular recognition processes involving the drug and its cellular targets.
In this chapter we will describe the most important NMR techniques developed to study molecular recognition processes involving proteins and nucleic acids also focusing on their application to drug discovery and development.
Carbohydrate moieties of cell glycoconjugates play a pivotal role in molecular recognition phenomena involved in the regulation of most biological systems and the changes observed in cell surface carbohydrates during cell activation or differentiation frequently modulate certain cell functions.
Numerical modelling studies of the kinetics of fibril formation at different protein concentrations, which included over 20 different possible assembly mechanisms, suggest that the initial molecular recognition events involve the assembly of monomers leading to the formation of a high-energy structural nucleus consisting of six β2m polypeptide chains.
Not only has this given rise to a widely accepted framework for the classification of base pairs in terms of their geometries (21), the concomitant evolution of the concept of isostericity (22) has established the importance of base pair shapes (and not simply their identities) as a major determinant in molecular recognition processes involving RNA.
Such an interaction is more consistent with PduS being a specific corrin reductase since it involves molecular recognition of cobalamin.
Heteromultivalency, which is defined as an interaction in which two or more different types of molecular recognition events take place simultaneously between the two interacting partners, is in fact a generalization of multivalency which involves multiple molecular recognition events of the same type between two entities.
The presence of disorder in human SIRT1 and the propensity of these proteins in promoting molecular interactions make it important to understand the underlying mechanisms of molecular recognition that reasonably should involve terminal segments.
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