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Our results provide new insights into engineering well-defined molecular recognition event on cell membrane to meet the demands of specific applications.
This approach is assessed for DNA recognition, demonstrating an increase in sensitivity by over one order of magnitude as compared to commercial slides, and the possibility of following in situ the molecular recognition event (hybridization).
Mutual conformational selection and population shift followed by minor induced-fit optimization is the key mechanism in biomolecular recognition, and monomers and small oligomers binding to amyloid seeds in fibril growth is a molecular recognition event.
To transduce a molecular recognition event to a fluorescence signal, a fluorophore-quencher pair is attached to opposite ends of the RNA substrate such that when the NAE cleaves the substrate, an increased level of fluorescence can be generated.
The double decker complex shows a large allosteric effect in this molecular recognition event (once rotation has been suppressed by the first guest molecule, guest binding becomes increasingly favorable).
Conformational selection and population shift is the key mechanism in biomolecular recognition, 56) and adding monomers and small oligomers to amyloid seeds in fibril growth(177) is a molecular recognition event.
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Enzyme substrate interactions represent an unexploited source of molecular recognition events.
Surface based analytical tools have gained more importance for rapid, sensitive and label-free monitoring of molecular recognition events.
Multipolar interactions have gained attention due to their roles in molecular recognition events of chemical and biological systems.
Variations in the measured parameters can be associated with either many individual molecular recognition events or with a specific uptake.
Molecular recognition events are at the core of almost every biological process, and are meant to remain an active area of research in both basic and applied realms.
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