With this effective molecular radius, it is then possible to determine the permeability-surface area product [ 27] as 2.5 × 10-4 mL/s × 100 g.
Moreover, the trend line of decreasing choroid-Bruch's membrane permeability with increasing solute lipophilicity and/or molecular radius appears to be steeper than the sclera.
As in other types of glomerular diseases, the primary main lesion in IMN is alteration of the glomerular filtration barrier (GFB) function with increased excretion of albumin (molecular radius, r =36 Å) and high molecular weight proteins such as IgG (r = 55 Å) and IgM (r = 120 Å) [ 13, 14].
It is assumed that the molecular radius of this product is around 7.5 nm, as compared with 4 nm for the HSA.
Here r 0 is the fullerene molecular radius, and m 0, its mass.
We used cellobiose for a molecule relatively large in molecular radius whereas many other studies used lactulose.
Gap junctions limit permeability to substances of less than 0.8 1 nm in molecular radius or less than 1 kDa.
For prodan, we calculated a molecular radius of 6.3 Å,[ 8] which compares well to our experimental value, a0=6.5±0.7 Å.
Small molecular weight compounds (<1000 D) typically have molecular radii of 10−10 m compared with the radius of a cell, 10−5 m.
In order to take account of this, the algorithm replaces the sum of the molecular radii by an effective binding radius, σ.
