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The blood samples treated with the LINAC can provide effective irradiated blood samples suitable for molecular profiling to validate radiobiological measurements via the gene-expression based biodosimetry tools.
Finding and isolating rare tumor cells in blood allows for diagnosis of disseminated cancer and for molecular profiling to direct the choice of biologic therapy.
Molecular profiling to identify targetable driver mutations is increasingly being applied in the clinic, and can stratify patient groups.
We showed that, with the use of appropriate statistical instruments, we could dissect the contribution of metabolites assessed through high-throughput molecular profiling to complex biological pathways.
The use of molecular profiling to identify tumours with differing proliferative and apoptotic signatures might provide valuable information in the future [ 30].
We have used histological evaluation and molecular profiling to determine gene expression changes in 23 human patients undergoing surgical procedures for the treatment of chronic tendinopathy.
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Other "branded and patented HRT consists of synthetic hormones that have a different molecular profile to those produced in the body".
Interestingly, we found that microfollicular adenomas (FTAb) were related by their molecular profiles to oncocytic adenomas as well as to carcinomas.
A 10-fold equivalent brain tissue mass was loaded for brains from mice showing H-type PrPres molecular profile than from those with a classical-like (C-like) PrPres molecular profile to obtain equivalent PrPres signals.
This permits tumors with similar molecular profiles to be classified according to biological attributes rather than anatomic location (e.g. Ewing's tumor family).
Microarray data are being used to categorize tumors on the basis of their molecular profiles, to identify subtypes of tumors, to predict patients' responses to treatment and risk of relapse, and to explore the biological properties of tumors [ 1- 7].
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