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With the emergence of robust immunohistochemical stains and the growing field of molecular profiling, there is an increasing need for validation of a tailored approach to therapy.
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As with many new technologies, there may be a social cost to molecular profiling.
Drug companies are intensely interested in ways of predicting which patients are likely to respond to chemotherapy, and there is some evidence that p53-and molecular profiling like it-may help identify patients likelier to respond.
There is an increasing interest in the molecular profiling of cancers.
The molecular biology of NETs is still poorly understood but there are emerging data to suggest that molecular profiling and identification of common genetic elements may enhance tumour classification and identify potential targets that may be involved in tumour progression.
There has been longstanding expectation that evolution in molecular profiling may result in pathological classification that more directly reflects the genetic aetiology of non-BRCA1/2 tumours.
Molecular profiling of activated B cells, isolated 7 days after immunization, indicated that there was early programming towards B-cell memory.
We evaluated the use of molecular profiling (MP) for metastatic salivary gland adenoid cystic carcinoma (SACC), for which there is no standard treatment.
Molecular profiling (MP) of tumors may be used to identify potential targets for which there are available therapies.
We also suggest that there is critical need for integrating data from a number of different molecular profiling methods such as proteomic, transcriptomic and metabonomic platforms.
There is thus a strong case for integrating information across multiple physiological levels, from molecular profiling (metabolomics, lipidomics, proteomics and transcriptomics) and brain imaging to cognitive assessments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com