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In this and many other cases, experts support case-by-case use of molecular profiling techniques for risk assessment.
In combination with several molecular profiling techniques, the "Mouse Avatar" and Co-clinical Trial concepts have the potential to revolutionize the drug development and health care process.
High-throughput molecular profiling techniques are excellent tools for the study of complex molecular alterations.
Molecular profiling techniques can be considered useful tools to address emerging biosafety gaps.
These findings stress the need to combine histopathological parameters with molecular profiling techniques for translation into clinical practice.
Long before the advent of modern molecular profiling techniques, histopathologists recognised that breast cancer was heterogeneous through morphological observations.
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Given the rarity of CTCs and the high possibility of contamination with non-tumor cells, the molecular profiling technique used for their analysis needs to be remarkably sensitive to be able to detect the tumor-specific aberrations.
Accordingly, our novel approach uses proteomics as a molecular profiling technique to identify potential unintended effects resulting from the interbreeding of GM varieties (e.g. synergistic or antagonistic interactions of the transgenic proteins).
The availability of molecular genome profiling techniques such as array CGH have markedly enhanced the resolution of chromosome studies and enabled high-resolution genome analysis, thus proving a more accurate method for the identification and delineation of chromosomal rearrangements (Vissers et al. 2003; Shaw-Smith et al. 2004; Cheung et al. 2005; de Vries et al. 2005; Johnston et al. 2007).
It is therefore perhaps not surprising to find that studies using molecular profiling (proteomic, metabolomic) techniques have found significant compositional differences between the GM line and non-GM isogenic parent.
The future of rational use of new targeted agents also depends on successful application of analytical techniques enabling molecular profiling of patients and leading to selection of likely therapy responders.
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