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A single platform designed for the synchronous screening of multiple mutations can potentially enable molecular profiling in samples of limited tumor tissue.
A Web site describes goals such as: "Integrate molecular profiling in early-stage and locally advanced lung cancer to increase number of patients who are cured by 10-20%." The program will also include public awareness campaigns to discourage smoking, for instance.
Some major clinical centers are now starting to use more comprehensive molecular profiling in clinical care.
Many centers and groups are assessing the potential of molecular profiling in the prediction of response to therapy.
Almost universal in phase I and II studies, it is now clear that molecular profiling in some form will be integral to many phase III studies as well.
Indeed, molecular profiling in CLL has allowed the identification of new genes for which the expression is dependent on CpG island methylation [ 13].
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Today, different data generated by the immunostained tissues are studied to achieve a molecular profile in different clinical scenarios.
Multiple reasons for this phenomenon have been discussed in the literature, with one reason being the lack of patient selection on the basis of molecular profile in clinical trials.
Here we generate a large-scale disease-disease, drug-drug and disease-drug network by directly matching their molecular profiles; in particular, their transcriptomic profiles thanks to the accumulation of whole-genome gene expression data available in the public domain.
In five patients, all NRs, the molecular profile in primary tumour and related distant metastatic sites was discordant.
Seven patients showed a molecular profile in the primary tumour superimposable with that observed in visceral metastases (Table 2).
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