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The role of EGF/EGFR dynamic interaction networks has been studied recently with either computational approaches [ 43], or by integration of molecular profiling, database and literature mining, mechanistic modeling, and cell culture experiments, demonstrating that EGF (among other growth factors) plays an important role in communication networks regulating blood stem cell fate decisions [ 44].
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Microarrays and other new high-throughput technologies of the past decade have made it possible to generate large molecular profile databases on clinical cancers and cultured cancer cells.
Additional features are available as plugin s which are available for network and molecular profiling analyses, new layouts, additional file format support, scripting, and connection with databases [ 13].
JNW directed the molecular profiling project, helped write the manuscript, and made input at every step of the database development.
Has your doctor spoken to you about molecular profiling and tumor testing?
Molecular profiling revealed a BRAF G469A mutation.
More recent molecular profiling initiatives have included broader NGS platforms.
Molecular profiling is performed as summarized in Fig. 3.
Molecular profiling of clinical specimens offers hope in two ways.
Molecular profiling is uniquely suited for multiplex assays.
In conclusion, our molecular profiling demonstrates that BRCA1-associated and BRCA2-associated tumors have distinct molecular profiles.
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