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At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis.
Bone has the unique capacity to heal without the formation of a fibrous scar, likely because several of the cellular and molecular processes governing bone healing recapitulate the events during skeletal development.
They provide a novel perspective on the complex signaling network regulating trophoblast development and can facilitate our understanding of the molecular processes governing placental morphogenesis in other species, including humans.
The molecular processes governing hematopoiesis involve the interplay between lineage-specific transcription factors and a series of epigenetic tags, including DNA methylation and covalent histone tail modifications such as acetylation, methylation phosphorylation, SUMOylation and ubiquitylation.
We were further interested in identifying potential molecular processes governing this phenotypic reversion of the activated state.
The inherent complexity involved in the molecular processes governing life has motivated the development of computational modeling and simulation techniques to decipher their ensemble dynamics.
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Moreover, research of the past decade has provided us with an enormous increase in the amount of data and knowledge on the cell-biological and to a even higher extent the molecular-genetic processes governing cell survival and death in cancer cells.
To gain molecular insight in the processes governing the malignant transformation of hepatocytes in DKO animals, we determined the activation of the major stress-dependent MAPK-signaling pathways.
RAS gene, serving as molecular switches in pivotal processes governing cellular growth and differentiation, have been found to be amplified and over expressed in gastric carcinomas[ 16, 17].
This study also highlights the independence of processes governing morphological and neutral molecular evolution [32], [33].
The integration of classical quantitative genetic studies with genomic data therefore provide an exciting opportunity for molecular ecologists to begin to understand the processes governing the evolution and maintenance of quantitative trait variation in wild populations.
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