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Ontologies available for EA workflow include the Canonical Pathway maps (signalling and metabolic maps created by Thompson Reuters' scientists by manual curation of literature), Process Networks (cellular and molecular processes defined and annotated by Thompson Reuters scientists).
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The complexity and multi-step nature of tumor initiation, maintenance and metastasis has hindered the elucidation of key molecular processes defining breast cancer progression.
The top 10 cellular and molecular processes were defined and annotated by GeneGo.
We thus believe that our study serves as a valuable resource to understand the molecular processes that define axonal injury-driven RGC death.
Those processes define sex differentiation.
Experimental targets were mapped onto functional ontologies in MetaCore, in particular GeneGo Process Networks, a set of ∼110 cellular and molecular processes where content is defined and annotated by GeneGo.
Non invasive imaging modalities capable of quantifying molecular processes in vivo (collectively defined as "molecular imaging" techniques) are extremely interesting in this respect.
There are about 110 cellular and molecular processes whose content is defined and annotated by GeneGo.
Epigenetic changes are broadly defined as "molecular processes around DNA that regulate genome activity independent of DNA sequence and are mitotically stable" (Skinner et al. 2010).
While the specific molecular processes responsible remain to be defined, the reduced γH2AX foci induction and their enhanced dispersal are consistent with a decrease in radiosensitivity.
Considering our current molecular understanding, epigenetics is defined as "molecular processes around DNA that regulate genome activity independent of DNA sequence and are mitotically stable" (Skinner et al. 2010).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com