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To shed light on the molecular processes controlled by HH-EGFR cooperation, we screened for downstream mediators of signal cooperation by genome-wide expression profiling of human HaCaT keratinocytes with either single activation of GLI1, EGFR or a combination of both signals.
The data validate EGFR signalling as drug target in HH/GLI driven cancers and shed light on the molecular processes controlled by HH-EGFR signal cooperation, providing new therapeutic strategies based on combined targeting of HH-EGFR signalling and selected downstream target genes.
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Now, emerging molecular tools have shed light on the molecular processes controlling these pathways.
Not only does the understanding of this mutualistic association hold the key to a better exploitation of a trait important in agriculture, it also provides insights into molecular processes controlling microbe recognition, pathogen defense and plant organogenesis.
The consistently sensitive parameters successfully pinpointed the TOC1 transcription as the sensitive component and the molecular processes controlling the model behaviours, whereas DOR indicated the much greater plausibility of the two-loop model compared with the one-loop model, supporting many biological findings.
And the results provided us new insight into the molecular processes controlling multicellular formation in tobacco.
Molecular processes controlling FA metabolism are highly interconnected and linked with related pathways, such as lipid, carbohydrate and energy metabolism.
The increasing knowledge about the molecular processes controlling cell division has led to the identification of a number of proteins held responsible for the genetic instability.
The presented data indicate a regulatory interaction of APPL proteins with the DNA repair kinase ATM, thus providing novel insights into molecular processes controlling cell fate and tumor cell resistance.
Epidemiological evidence implicates that Chk2 and BRCA1 are in the same breast cancer prevention pathway [ 112], which is supported by the molecular process controlled by their interaction.
However, the molecular process controlling FA composition and metabolism is far from being fully understood.
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