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To conclusively satisfy "Koch's molecular postulates" for the biological role of Vsp's, genetic tools for the manipulation of B. turicatae need to be developed.
More recently, molecular postulates were introduced to unravel mechanisms associated to virulence [ 9].
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Although mechanisms of alcoholism remain to be elucidated, the molecular hypothesis postulates that that alcohol dependence and toxicity result from neuroadaptations to chronic alcohol consumption based on alterations in gene expression.
The neutral theory of molecular evolution postulates that functionally important genes evolve more slowly than the less important genes (Hirsh and Fraser 2001; Jordan et al. 2002; Liao et al. 2006).
Molecular genetics postulate ARVC to be a "disease of the desmosome".
The molecular Koch's postulates are a set of criteria formulated by the microbiologist Falkow 88 based on Koch's postulates, to establish the causation of or contribution to disease by specific genes or virulence factors found in pathogenic microbes.
Several criteria have been suggested to help formalize this process including molecular Koch's postulates or adoption of Hill's criteria [3], [4].
The contribution of a gene to bacterial virulence is defined by the molecular Koch's postulates [ 13].
In vivo virulence of these factors has been established in animal models fulfilling the paradigm of "Molecular Koch's postulates".
Since the 1980s, the dominant paradigm for linking genes to phenotype in microbiology has been based on the Molecular Koch's Postulates, outlined by Falkow [ 65].
Molecular Koch's Postulates are often used as a stringent standard for validation, although the original article offered a nuanced discussion of some of the difficulties in their application to all situations [ 65].
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