Sentence examples for molecular platform to from inspiring English sources

Here we profit from this optimized electrocatalytic molecular platform to design new molecular wires that connect a metal nanoscale junction in a highly efficient and tunable way.

USF acts as a molecular platform to recruit distinct transcription factors and cofactors in response to fasting/refeeding via its ability to strongly bind to E-box regulatory elements (Latasa et al., 2003).

Mitochondria are central regulators of pyrin domains-containing 3 (NLRP3) inflammasome's activation (Gurung et al., 2015); inflammasome is a molecular platform to activate innate immune defense and pyroptosis through several pro-inflammatory cytokines and its interaction with caspase-1 (Schroder and Tschopp, 2010; Strowig et al., 2012).

As the site of assembly of the transcription initiation machinery, the core promoter serves as a molecular platform to integrate regulatory signals delivered by upstream silencer and enhancer elements to appropriately adjust the level of promoter activity [2], [4], [6], [24] [26].

The NALP1 inflammasome, which was the first nucleotide binding and oligomerization domain (NOD -like receptor (NOD -likely moleculareceptorrm to be ideNLRfamilyis relatively widely expressed and is comolecular NALplatformdaptor known as apoptosis-associated speck-like protein containing card (ASC), and caspase-1 [41], [42].

To that end, synthetic polymers have been widely investigated as a new molecular platform to create antimicrobial agents that are active against drug-resistant bacteria.

Within breast cancer research, perhaps, the best contemporary example is the recent analysis of 466 breast cancers by The Cancer Genome Atlas Network that integrated analysis from various molecular platforms to produce a comprehensive portrait of genetic and epigenetic alterations (Cancer Genome Atlas Network, 2012).

PCNA is a ring-shaped protein that encircles DNA and, via protein-binding sites located on the outer surface of the ring, functions as a molecular platform at the replication fork to recruit numerous replication-associated enzymes (Vivona and Kelman, 2003; Moldovan et al, 2007).

It is able to recruit different players in controlling gene expression, organizing a molecular platform able to specifically retrieve target sequences.

These results demonstrate that chronic SCI initiates the coalescing of the NLRP3 molecular platform leading to the activation of caspase-1, IL-1β, and IL-18 in VAT and pancreas.

Our data indicate that mitochondrial AMBRA1 induces (1) relocalization of the mitochondrial network around the nucleus, (2) depolarization and ubiquitylation of mitochondria and (3) recruitment of the molecular platform necessary to induce functional mitophagy through a PARKIN/p62-independent pathway.