Sentence examples for molecular phenotypes defined from inspiring English sources

Such molecular phenotypes defined pre-clinically may ultimately impact on the evaluation of a particular drug in a living cell.

Based upon the association of SOX2 and CDX2 with worse and better survival as well as more and less aggressive clinicopathological features, respectively, we further studied patients' outcome according to the molecular phenotypes defined by both proteins.

We further explored the impact in patients' survival of the molecular phenotypes defined by SOX2+ vs SOX2-, CDX2+ vs CDX2- and SOX2-/CDX2+ verSOX2+/CDX2CDX2- stratified according to clinicopathological parameters.

With the recorded clinical and molecular parameters during the full EAE experiment (susceptibility, severity and molecular phenotypes), we defined clusters of gene networks that had a direct relation to clinical characteristics of disease.

Specific to the adjuvant therapy setting, broader use of molecular phenotyping to define tumours that are likely to be most susceptible to aspirin exposure (i.e., based on increased COX-2 expression) could improve the response rate.

Snapshot overviews of mRNA expression changes that underlie cellular phenotypes define transcript expression differences, gene ontology re-organization, and gene network remodeling events that can be mapped in silico to extract novel molecular information [ 9].

This mutator phenotype defined a specific molecular pathway for colon cancer because the mutated cancer genes are in general different than those from cancers without MSI [ 10, 11].

Gene expression profiling has been used to define molecular phenotypes of complex diseases such as breast cancer.

We define molecular phenotypes as the biomolecular manifestation of a gene sequence, which encompasses proteins, enzymes (proteome), and metabolite concentrations (metabolic phenotype).

ER is phenotype defined based on the activity of estrogen receptor on the tumor [ 13] and has clear related molecular mechanism, the consistency degree between this endpoint phenotype and gene expression profile is relative high.

Moreover, SOX2 expression predicted poorer patient survival, and the combination with CDX2 defined two molecular phenotypes, SOX2+CDX2- versus SOX2-CDX2+, that predict the worst and the best long-term patients' outcome.