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Here, we review recent developments in omics profiling of various molecular phenotypes and the emergence of human iPSCs as a systems biology model of human diseases.
de Rinaldis, E. et al. Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control.
Gene expression levels measured by microarrays represent molecular phenotypes and will require additional research to identify the underlying genetic changes driving variation in expression levels [57].
Mammals have four types of TCs (Types I, II, III, and IV) within their taste buds and these cell types exhibit different molecular phenotypes and functional roles.
An important environmental condition for monitoring molecular phenotypes and characterizing their association with metabolic traits is feeding status.
Moreover, it is hoped, but not ascertained, that CTCs represent mixtures of tumor cells that reflect the full spectrum of molecular phenotypes and genotypes present in multiple metastases.
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Williams, M. C. Alveolar type I cells: molecular phenotype and development.
Future trials should include molecular phenotyping and selection of patients most likely to benefit from targeted therapies.
Moreover, to illustrate the relationship between the local molecular phenotype and TCR repertoire of the microenvironment, whole-genome gene expression microarray analysis of the corresponding gastric precancerous lesions and early gastric cancer tissues was conducted.
Al-Nbaheen M, Vishnubalaji R, Ali D, Bouslimi A, Al-Jassir F, Megges M et al. Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential.
What action threshold criteria should be adopted in adaptive radiotherapy to conform to changing morphology, molecular phenotype, and respiratory-induced tumor motion patterns?
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