Sentence examples for molecular phenotype that from inspiring English sources

These results suggest that Src inhibitors combined with oxaliplatin may have efficacy in metastatic colon cancer and may provide the first indication of a molecular phenotype that might be susceptible to such combinations.

Taken together, our results suggest that SATB1 is sufficient to induce in immature MGE precursors a molecular phenotype that is normally encountered in mature SST+ cortical interneurons.

Atrial supply-demand ischaemia has also been proposed as a potential trigger for atrial structural remodelling and has a molecular phenotype that resembles changes seen in hibernating ventricular myocardium.

If these disease-related cells can be shown to have a cellular or molecular phenotype that is related to the disease, they can be used to develop a screening assay and subsequently, collections of thousands of different compounds can be screened to identify those that prevent the disease phenotype.

From the novel observations reported herein it is apparent that POECs isolated from HIV+ (O/H) subjects represents a molecular phenotype that is different from those isolated from healthy controls and that the retarded growth phenotype is stable upon cell duplication, consistent with epigenetic alterations.

Aortic aneurysm progression in Fbn1 C1039G/+ and Fbn1 mgR/mgR mice is largely driven by increased latent TGF-β activation and signaling secondary to loss of TGF-β-LLC sequestration in the ECM, a molecular phenotype that is replicated in cultured primary smooth muscle cell isolated from Fbn1 mutant aortas [ 46, 47].

This new phase enhances GTEx to measure, in addition to gene expression levels, a diversity of molecular phenotypes that may ultimately influence human disease.

Metabolomics is therefore a tool for defining observable molecular characteristics (or molecular phenotypes) that are associated with metabolism.

Whole-genome expression profiling provides global molecular phenotypes that enable functional analyses of genes and genomes.

Gu [ 25, 26] postulated that molecular evolution of a gene in a K-dimensional space of molecular phenotypes that represent the multi-functionality of the encoding protein.

These proof-of-principle studies showed that these stem cell-derived beta cells show molecular phenotypes that recapitulate those seen in the patient.