Sentence examples for molecular phenotype observed from inspiring English sources

This finding contrasts with the molecular phenotype observed in our patients with a novel mutation in the C-terminus of DSG2.

We further show that this regional identity is lost following abrogation of Nodal/activin signaling, which as reviewed previously (Godard and Mazan, 2013) is reminiscent of the molecular phenotype observed in the mouse embryonic visceral endoderm (Mesnard et al., 2006).

These pre-rRNA processing defects are consistent with the nucleolar accumulation observed with the D-A2 probe by FISH, and resembles the molecular phenotypes observed upon depletion of Nhp2p or Utp15p: Utp15p was proposed to be required for optimal rRNA synthesis [2], [11], whereas Nhp2p depletion led to an A0-A1-A2 cleavage defect [10].

The cartilage and molecular phenotypes observed in our genetic studies combined with our in vitro molecular data demonstrate that RBPjk-dependent Notch signaling coordinates the onset of chondrocyte maturation and cartilage growth largely via indirect regulation of Sox9.

We further hypothesize that variation in the different cellular and molecular phenotypes observed in E2 treated ACI and BN rats is representative of variation that would exist within the genetically heterogeneous human population.

A reasonable course of action to address this issue would be to determine whether the cellular and molecular phenotypes observed in RTT- and SCZD-hiPSC-derived neurons are recapitulated following the reprogramming of fibroblasts from the same patients directly to iNeurons.

In support for the involvement of raft alterations in the aberrant molecular phenotype we observed that, although raft abundance does not appear to be significantly affected since the raft bona fide marker flotillin is not altered, the presence of RhoA in raft domains is reduced in ASMko synaptosomes compared to wt (Supplementary Fig 6).

Gene profiling of the LV transcriptome was performed to uncover the molecular basis for the cardioprotective phenotype observed in LXRα-Tg mice (Supplementary Fig S3, Supplementary Table S3).

However, the overarching notion is that similar or identical molecular pathways should underlie the phenotype observed in either tool or model as are affected in the human disorder.

In this issue of EMBO Molecular Medicine, Kollmann et al (2013) report on their studies of the molecular mechanisms underlying the skeletal phenotype observed in MLII.

If these results can be definitively verified across host species, it may indicate a molecular basis for differences in clinical phenotype observed between the two genetic groups.