Thus, our observations that ER-positive (effectively luminal A and B) tumours are different in the relationship of TSR to outcome is most probably a mirror to the effect of diverse molecular phenotype underpinning the biological differences.
Furthermore, the promoter regions of differentially expressed genes between A. oryzae and A. flavus did not show TR enrichment, suggesting that genome-wide differences in molecular phenotype between the two species are not significantly associated with TRs.
If TRs played an important role in supplying rapid phenotypic variation to populations experiencing unique selective pressures, such as ones undergoing domestication (Fondon and Garner 2004), we would expect to observe that differences in molecular phenotype between species are significantly enriched with TR-containing loci.
Though our study did not find a difference in effect by tumour molecular phenotype, larger molecular studies should be conducted to examine if such differences exist.
The levels of the activated ERK1/2 were significantly higher in the Grey horse samples, most likely reflecting a difference in the underlying molecular phenotype and/or melanoma stage.
The auhors found higher rates of LNM in the multifocal group, interestingly no differences with respect to molecular phenotype [ 29].
We describe a model consisting of in vitro cultured endothelial cells isolated from human normal and neoplastic specimens that maintained their respective molecular phenotype and enabled us to determine molecular differences between tumor and normal tissue derived EC.
H-type and L-type BSE are prion diseases of cattle with distinct differences in the pathological and molecular phenotype, which are maintained after experimental transmission of naturally occurring disease to cattle [ 4, 5, 15].
However, the differences between good and poor responders are notable and provide evidence for variation in molecular phenotype contributing to aggressiveness within the same histologic subtype of tumor.
How cancer cells acquire a specific molecular phenotype is uncertain.
